Adaptive Admixture of HLA Class I Allotypes Enhanced Genetically Determined Strength of Natural Killer Cells in East Asians

Abstract Human natural killer (NK) cells are essential for controlling infection, cancer, and fetal development. NK cell functions modulated by interactions between polymorphic inhibitory immunoglobulin-like receptors (KIR) HLA-A, -B, -C ligands expressed on tissue cells. All HLA-C alleles encode a KIR ligand contribute to reproduction immunity. In contrast, only some HLA-A -B they focus By high-resolution analysis of genes, we show that the Chinese Southern Han (CHS) significantly enriched -B. This enrichment has had substantial input through population admixture with neighboring populations, who contributed HLA class I haplotypes expressing B*46:01 B*58:01, which subsequently rose high frequency selection. Consequently, over 80% more than one ligand. Complementing number ligands, CHS locus combines genes potent KIR, low those activating KIR. The centromeric region encodes strong, conserved, HLA-C-specific receptors, telomeric provides diversity -B-specific receptors. all these characteristics, represent other East Asians, whose repertoires thus enhanced in quantity, diversity, effector strength, likely augmenting resistance endemic viral infections.